Abstract Background Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. These tissues act as your body's first line of defense against infections. Tongue musculature involvement can cause restricted movement, dysarthria, and dysphagia. The therapeutic response is related to the pathological subtype and several factors, such as old age, high grade histology, bulky lymph nodes, higher IPI score, and advanced stage [22, 24, 25]. Authors M Gromet , M J Homer , B L Carter PMID: 7111732 DOI: 10.1148/radiology.144.4.7111732 No abstract available Publication types Case Reports MeSH terms Adult Barium Sulfate Deglutition Diagnosis, Differential Female In the literature, findings of RLH are well-documented. PMC Upon examination with direct laryngoscopy a large, multiloculated, exophytic mass was identified, emanating from the oropharynx and extending distally to the level of the supraglottis, occupying >90% of the upper aerodigestive tract. Work-up of globus: assessing the benefits of neck ultrasound and videofluorography. Chemotherapy containing rituximab was considered to significantly improve survival in DLBCL and MCL patients [39, 43]. 39, no. ZL, BW, XR and YC reviewed all the cases together. official website and that any information you provide is encrypted The https:// ensures that you are connecting to the Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma, not otherwise specified. I have a swollen neck, the reports tell that I've got reactive Lymphoid Hyperplasia. Xinyu Ren and Yin Cheng contributed equally to this work. Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. These cells are designed to fight. Benign Lymphoid Hyperplasia of the Tongue Base Causing Upper Airway Obstruction Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. Squamous cell hyperplasia in the oral cavity is seen most commonly on the tongue, palate, and lateral wall of the pharynx. Figure 2 shows the process of a reactive lymphoid lesion histologically. 172175, 2003. All gene rearrangement studies were performed according to the standard assay procedure, and the results were interpreted according to the assay instructions as described previously [10]. [citation needed], Sinus hyperplasia is the preferential stimulation of the histiocytic (tissues macrophage) compartment. CD30 antibodies were purchased from Maixin Biotech. What are the symptoms and prognosis for a benign reactive lymphoid hyperplasia of the neck lymph node? Others theorize that it is caused by compensatory lymphoid hyperplasia after an adenotonsillectomy.19,20 Hypertrophied lymphoid follicles in the lingual tonsils of adults has been previously associated with the signs and symptoms of GERD.10 Mamede et al9 have suggested a possible link between the hypertrophy of the base of tongue and . All rights reserved. From: The Teaching Files: Chest, 2010 View all Topics 2017;18:27815. Formalin-fixed, paraffin-embedded tissue blocks of enrolled cases were used to make three-micrometer-thick sections. Lymphoid hyperplasia at the base of the tongue. Baran et al. XS and QL did the HPV ISH. The possible reason was that the patient had several high risk factors, such as old age (in his nineties), positivity for c-Myc and P53, and co-expression of c-Myc (50%), Bcl-2 and Bcl-6 [38]. All authors read and approved the final manuscript. A. Kolokotronis, I. Dimitrakopoulos, and A. Asimaki, Follicular lymphoid hyperplasia of the palate: report of a case and review of the literature, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. Epub 2018 Jun 25. When oral aggregates appear in clusters or have an unusual appearance or enlargement, clinicians may question whether abnormalities are present. ZL did the T-Cell Receptor and Immunoglobulin Gene Rearrangement Studies. [3] Follicular hyperplasia must be distinguished from follicular lymphoma (bcl-2 protein is expressed in neoplastic follicles, but not reactive follicles). Oral and Maxillofacial Pathology. Cancer that develops in the base of the tongue is a type of head and neck cancer. https://doi.org/10.4103/0019-509X.58873. Depending upon the location of the RLH, the appearance of tissue may vary. Severe HBT was considered to be present when the follicles prevented the view of the epiglottis or were massively distributed through the pharynx and larynx. 2014;10:94550. Lymphoma is the second most common primary malignancy occurring in the head and neck behind squamous cell carcinoma, while NHL accounts for 6590% of all lymphomas occurring in the head and neck [1, 2] .2030% of NHLs are derived from extra-nodal sites [3] .Nonetheless, NHL with a primary site in the oral cavity is rare, and in the tongue base, even rarer [4, 5]. https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV. Russo S, Lo Re G, Galia M, Reginelli A, Lo Greco V, D'Agostino T, La Tona G, Coppolino F, Grassi R, Midiri M, Lagalla R. Radiol Med. [36] showed that patients with DLBCL located on Waldeyers ring (base of the tongue) often have a better prognosis than nodal DLBCL patients. Like all lymphoid tissue in the body, oral lymphoid tissue is highly reactive and can enlarge from time to time as it reacts to foreign entities. [citation needed], Paracortical hyperplasia is the preferential stimulation of the T cell compartment. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Although our case with MCL received rituximab during his second cycle of chemotherapy, he relapsed two years after the primary diagnosis. Nuclei were counterstained with hematoxylin. Burkitt's lymphoma of the base of the tongue: a case report and review of the literature. As stated before, the depth of invasion is a major prognostic indicator. [Lymphoepithelial hyperplasia of the tonsil at the base of the tongue]. 2010;39:86972. EBV ISH was performed using EBV-encoded Small RNA (EBER) probes (Bond ready-to-use ISH, Catalogue No: PB0589, Leica Biosystems Newcastle, Ltd.) according to the manufacturers protocol. Similarly, the inner cortex has T cells and is called the T-cell zone. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. Immunohistochemical staining was performed using a Ventana Benchmark XT Autostainer (Ventana Medical Systems, Inc., Tucson, AZ). Baran M, Canoz O, Altuntas H, Sivgin S, Cetin M, Yay A, Ketenci S. Immunohistochemical investigation of P16, P53 and Ki-67's prognostic values in diffuse large B-cell lymphomas. This is an open access article distributed under the. The exceptional case here was a 45-year-old male patient with diffuse large B cell lymphoma who presented with only deep painful mouth ulcers and general symptoms, including sore throat, choking when drinking water, and difficulty swallowing. The most common symptoms are varying degrees of discomfort in the pharynx, such as the sensation of a foreign body or choking while drinking. This study was supported by grants from CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-002). The follow-up period started from the date of diagnosis until August 30, 2019, and ranged from 3 to 90months. 2017;118:6028. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. 1987;149:57581. To the best of our knowledge, four cases have been reported, including our case and three cases from literature (Table 5) [17, 27, 40]. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Roentgen examination of the oropharynx and oral cavity. Lewis JS Jr. Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: catch me if you can! There were two main cytomorphological variants of the DLBCL, NOS cases: centroblastic and immunoblastic. Understanding the biological behavior of and therapeutic options for tongue lymphoma is difficult due to the paucity of cases. Semin Oncol. Positive staining was indicated by brown punctate dots in the cytoplasm. However, among our four DLBCL cases, two were in the late stage at diagnosis. Shimada K. Molecular pathogenesis and treatment strategy in diffuse large B-cell lymphoma. Int J Hematol. DLBCL with high risk factors and MCL may have unfavourable outcomes. Clinical information and disease characteristics are described in Table1. Lymphomas of the head and neck: CT findings at initial presentation. Lee YY, Van Tassel P, Nauert C, North LB, Jing BS. e. Tumour cells were positive for Cyclin D1 (200x). 2006;17:143440. 2004;103:27582. All cases were reviewed and diagnoses were confirmed based on basic morphology, immunohistochemistry staining, and rearrangement. c. Immunohistochemistry staining showed diffuse and strong staining of P16 protein (40 x) d. Immunohistochemistry staining showed diffuse and strong staining of P16 protein (100 x). It has been historically referred to as reactive lymphoid hyperplasia or pseudolymphoma [1]. https://doi.org/10.1053/ajot.2000.8382. statement and https://doi.org/10.1159/000278291. Primary extra-nodal non-Hodgkin's lymphoma of the cheek. J Cancer Res Ther. https://doi.org/10.1016/j.ijom.2004.08.009. c. Tumour cells diffusely expressed CD20 (200 x). The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. A case of benign. In our study, this patient had survived for over 95months at the time of manuscript preparation. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. By using our website, you consent to our use of cookies. One case was P53 positive (Fig. What does prominent lymphoid tissue at base of tongue on an MRI report mean. Am J Gastroenterol. She was awarded the Dental Professional of the Year in 2017 through the International Pemphigus and Pemphigoid Foundation and is a 2017 Sunstar/RDH Award of Distinction recipient. Harabuchi Y, Tsubota H, Ohguro S, Himi T, Asakura K, Kataura A, Ohuchi A, Hareyama M. Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring. Discussions concentrating on NHL of the base of the tongue have focused on the histopathology and lack details regarding progress in the treatment response and prognosis. Arch Pathol Lab Med. 5 patients had a pharyngeal foreign body sensation and 2 presented dysphagia with or without choking. National Library of Medicine Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. Epub 2009 Jun 26. PTCL, NOS occurring at the base of the tongue are rare. https://doi.org/10.1093/annonc/mdl131. Bookshelf Regezi JA, Sciubba JJ, Jordan RCK. f. Tumour cells were negative for CD5 (200 x). This may have been due to the expression of the cytotoxic marker TIA, Granzyme B, and a much higher Ki-67 index (80%), which may indicate a poor prognosis [41]. J Clin Oncol. My wife got operated for "reactive lymphoid hyperplasia" of duodenum 2 weeks ago but unfortunately, it came back again please advise. Squamous cell hyperplasia is characterized by increased cell numbers, which usually results in increased thickness of the squamous epithelium. Immunohistochemically, the atypical lymphoid cells were positive for CD20, CD79a, PAX-5, CD5, CyclinD1 protein, and Ki-67 antigen (labelling 25%). Lee JH, Lee SH. Dr. Burkhart was awarded an affiliate fellow status in the American Academy of Oral Medicine in 2016. Google Scholar. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. Objective: This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. Oral-cutaneous CD4-positive T-cell lymphoma: a study of two patients. Ann Oncol. 2023 BioMed Central Ltd unless otherwise stated. This distribution is similar to that in previous reports [18,19,20,21,22] .The most common location was the base of the tongue. Departments of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Dongdan district Shuaifuyuan 1st, 100730, Beijing, China, Xinyu Ren,Shafei Wu,Xuan Zeng,Xiaohua Shi,Qing Ling&Zhiyong Liang, Departments of Pathology, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing, 100045, China, Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA, Department of Pathology and Otolaryngology, UC Irvine School of Medicine, UC Irvine Medical Center, Irvine, USA, You can also search for this author in Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status, https://doi.org/10.1186/s13000-020-00936-w, https://doi.org/10.1016/S0344-0338(11)80514-5, https://doi.org/10.1016/j.kjms.2012.02.014, https://doi.org/10.1080/02841860500531682, https://doi.org/10.1038/modpathol.2016.152, https://doi.org/10.1007/s00428-014-1682-7, https://doi.org/10.1038/modpathol.2011.45, https://doi.org/10.1182/blood-2003-05-1545, https://doi.org/10.1038/modpathol.3880541, https://doi.org/10.1097/01.dad.0000246949.49071.17, https://doi.org/10.1007/s12185-008-0142-z, https://doi.org/10.1016/j.ijom.2004.08.009, https://doi.org/10.1016/j.ijom.2010.03.029, https://doi.org/10.1016/j.anndiagpath.2005.09.020, https://doi.org/10.1016/j.oooo.2014.06.002, https://doi.org/10.1007/978-3-319-22822-8_13, https://doi.org/10.22034/APJCP.2017.18.10.2781, https://doi.org/10.1016/j.leukres.2005.11.004, https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV, https://doi.org/10.11406/rinketsu.58.2033, https://doi.org/10.1017/s0022215100142288, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. Unable to load your collection due to an error, Unable to load your delegates due to an error. When the lymphoid tissue is deeply seated, the appearance may be more pink or deeper in color. Guastafierro S, Falcone U, Celentano M, Cappabianca S, Giudice A, Colella G. Primary mantle-cell non-Hodgkin's lymphoma of the tongue. Asian Pac J Cancer Prev. The follicles are cytologically polymorphous, are often polarized, and vary in size and shape. Please enable it to take advantage of the complete set of features! Virchows Arch. Among our cases, there were 1 GC and 3 NGC cases. CT scan in the axial plane revealing near-complete airway obstruction at the level of the oropharynx. 2000;46:2112. Only one patient died of the disease. A man in his fourth decade was admitted with pharyngeal foreign body sensation for two months. There is usually a bilateral . Article government site. Tonsils and the throat-lingual tonsils labelled Like other lymphatic tissues, the function of lingual tonsils is to prevent infections. https://doi.org/10.1016/j.anndiagpath.2005.09.020. Lopez-Guillermo et al. https://doi.org/10.1002/cncr.27988. Int J Oral Maxillofac Surg. Viral infections, such as HIV or hepatitis C virus (HCV), can also develop in immunocompromised patients. The site is secure. Most of these cancers are squamous cell carcinoma and caused by human papillomavirus (HPV) infection. 1984 Apr;151(1):123-6. doi: 10.1148/radiology.151.1.6322222. Her IPI score was 3 (high risk group). This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. e. Tumour cells were positive for CD4 (200x). a. MRI showed a mass in the base of the tongue sticking to the pharyngeal cavity and making it obviously narrow. B. C. Jham, N. O. Binmadi, M. A. Scheper et al., Follicular lymphoid hyperplasia of the palate: case report and literature review, Journal of Cranio-Maxillofacial Surgery, vol. As they mount an immune response, lymphoid cells can proliferate and enlarge. 7982, 2009. Severe benign LH is unusual in the head and neck region, but the diagnosis should be entertained on the part of the clinician both clinically and histologically when lymphoma is suspectedparticularly in the oral cavity. Is it always necessary to carry out a biopsy on lymphoid hyperplasia or is endoscopic examination and MRI enough to decide that it is benign? Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. Lymphoid Hyperplasia i was referred to ENT by my GP because of a recurring sore throat. Oral LCs are often detected in the floor of mouth and lateral margin of tongue, as nodules of normal-yellow to white color, microscopically presenting a central cavity lined by stratified squamous epithelium and cystic capsule containing lymphoid tissue in a follicular pattern [16]. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, et al. In addition, patients may notice irregularities on their own, thereby bringing the appearance to the attention of their dentists or hygienists. 2006;45:25871. In terms of pathological characteristics, 6 patients were diagnosed with B-cell NHL, and 1 patient was diagnosed with PTCL, NOS (Table2). In the literature, the patients with peripheral T cell lymphoma of the tongue base were middle aged with no obvious differences in gender distribution. All authors read and approved the final manuscript. While an association with bacterial infection has not been clearly identified, one aggressive case of FLH has been linked to the presence of Epstein-Barr virus, causing clonal arrangement (expansion) in the local tissue DNA [4]. Tongue base lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon benign entity associated with a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. At the time of manuscript preparation, there were only four articles indexed in Medline that described PTCL and tongue involvement (Table 4, [12,13,14,15]). Follicular lymphoid hyperplasia (FLH) is a benign lymphoproliferative process of unknown etiology, uncommon in the head and neck region. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. Cutaneous lymphoid hyperplasia is generally not malignant, but in rare cases an association has been observed. PMC .. Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status. Bethesda, MD 20894, Web Policies Four treatment response classes were defined, as follows: complete response (CR, 100% resolution); partial response (PR, 50100% resolution); no response (<50% resolution); and progression of disease (PD, tumour enlarged after treatment). A finding indicating enlargement of the tongue. For the in situ detection of high-risk HPV integration at the mRNA level, the RNAscope FFPE 2.5 HD detection kit (Brown) (CAT #322310) was used according to the manufacturers instructions. The DLBCL, NOS cases were further divided into GC and NGC B cell like subtypes based on immunohistochemical expression of CD10, Bcl-6 and Mum1 [11]. Imaging and pathological findings of PTCL (case 3). 1997;76:356. Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. Except in one case of four, all of our patients were alive through follow-up. he started bty saying 90% of urgent referrals were viral so should be fine. Review of the preoperative anaesthesia records revealed no features of airway obstruction nor B symptoms on clinical history. The patient was kept on a three-week course of tapering prednisone and proton-pump inhibitors. 349356, 1980. In the middle power view, there were plenty of moderate to large cells with distorted nuclear contours (Fig. External beam radiation has been successful in a single case [6]. Etemad-Moghadam S, Tirgary F, Keshavarz S, Alaeddini M. Head and neck non-Hodgkin's lymphoma: a 20-year demographic study of 381 cases. The complaints due to severe HBT were noisy respiration, hoarseness, throat clearing, dry cough, globus pharyngeus, and nasal voice. Three patients (cases 1, 2, 7) received R-CHOP, 3 (cases 46) patients received CHOP, and 1 patient (case 3) received GDP and CHOP therapy. This may be because the case occurred before drugs such as rituximab were widely available. J Postgrad Med. One of the DLBCL cases was positive for HPV DNA and diffusely expressed P16 protein. The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. Accessibility ENT manifestations of gastroesophageal reflux. https://doi.org/10.1007/978-3-319-22822-8_13. Gastroesophageal reflux in bronchial asthma patients. https://doi.org/10.4149/BLL_2017_116. 4th ed. Pathobiology. Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, Forastiere A, Gillison ML. Federal government websites often end in .gov or .mil. All these factors might explain why the patient survived only 3months after diagnosis although he was in an early stage and had a low IPI score. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. b. H&E showed immunoblastic large cells with an obvious nucleolus (200 x). Eur Arch Otorhinolaryngol. TIA, SOX10 was obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China. Rasmussen PK. 2000;113:5128. Curr Allergy Asthma Rep. 2008 May;8(3):240-4. doi: 10.1007/s11882-008-0040-8. Non-Hodgkins lymphoma (NHL) primarily derived from the base of the tongue, is rare. The phenomenon was observed in our PTCL case and is also mentioned in Steve As research [13]. 1991;6(3):170-8. doi: 10.1007/BF02493520. 5760, 1993. Kaohsiung J Med Sci. Maheshwari GK, Baboo HA, Gopal U, Wadhwa MK. 2016;20:332. https://doi.org/10.4103/0973-029X.185926. https://doi.org/10.1093/jnci/djn011. When on the surface tissue, there may be a yellow, white, or even vesicular appearance, as seen in Figure 1. https://www.linkedin.com/showcase/4000114/. Dr. Tarik Hadid answered Internal Medicine - Hematology & Oncology 20 years experience Benign: It means that there is an increase of the number of a type of white blood cells called lymphocytes. Most DLBCL cases of the tongue base had no Bcl-2, Bcl-6, or c-Myc rearrangement and they were sensitive to rituximab. Studies on the survival time for patients with DLBCL in the head and neck are controversial [24, 36, 37]; here, we added that lymphoma arising from the base of the tongue has a good prognosis. Cases of DLBCL, NOS were further divided based on immunohistochemistry into two subtypes, GC and NGC. Unauthorized use of these marks is strictly prohibited. Head Neck. Nancy W. Burkhart, EdD, BSDH, AFAAOM, is an adjunct associate professor in the Department of Periodontics-Stomatology, College of Dentistry, Texas A&M University, Dallas, Texas. 7th ed. Sirsath NT, Lakshmaiah KC, Das U, Lokanatha D, Chennagiri SP, Ramarao C. Primary extranodal non-Hodgkin's lymphoma of oral cavity--a single Centre retrospective study. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other abusable medications. As shown in Table1, all primary lesion locations were considered at the base of the tongue. Bratisl Lek Listy. Positive and negative controls were included in each batch of staining. Reference Sands and Tewfik 1 The aetiology is poorly understood, . Extranodal NHL is complicated; it consists of a group of tumours with different pathological, clinical and prognostic characteristics [6] .Existing series presenting extranodal NHL have mainly summarized the tumours that occur in the head and neck but are not specific to the base of the tongue. An official website of the United States government. In summary, NHLs in the base of the tongue are rare with nonspecific symptoms of oropharyngeal discomfort, and they could present with normal-like mucosal surfaces. The biological behaviours that are exclusive to the tongue base are not clear. The most common site for all cases was at the base of the tongue. PubMedGoogle Scholar. Examination and imaging (CT and MRI) showed a mass (4.6cm2.8cm1.5cm) at the left base of the tongue, which was biopsied. Uherova P, Ross CW, Finn WG, Singleton TP, Kansal R, Schnitzer B. For NHL of the head and neck, there is a logarithmic increase in incidence with increasing age [18] .The average age at disease diagnosis was 61.8years and there were no observed gender differences. Unable to load your collection due to an error, Unable to load your delegates due to an error. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. When we think of lymphoid hyperplasia in the oral cavity, we often think of localized increases of lymph node tissue. Video chat with a U.S. board-certified doctor 24/7 in a minute. https://doi.org/10.1097/01.dad.0000246949.49071.17. Diagnostic Pathology Please enable it to take advantage of the complete set of features! As always, continue to ask good questions and listen to what your patients are telling you! The remaining five patients were alive through the end of follow up. One case presented as multiple deep ulcers. Head and neck extranodal lymphoma in a single institute: a 17-year retrospective analysis. Accessibility Am J Dermatopathol. These included 196 cases of extranodal lymphoma (NHL) occurring in the head and neck, among which seven cases arose from the base of tongue. Manage cookies/Do not sell my data we use in the preference centre. 2015;466:93100. Cytoplasmic staining was used for ALK, TIA, AE1/AE3. Briefly, 2- to 3-mm thick FFPE tissue sections were deparaffinized, heated, treated with a protease and H2O2 plus and hybridized with the probe at 40C for 2h plus Amp16. A poor prognostic case of peripheral T-cell lymphoma in the base of tongue with chemotherapy followed by radiation therapy. Nathu RM, Mendenhall NP, Almasri NM, Lynch JW. What are chaces of malignancy?What precautions for future shud i take? PET-CT/CT/MRI scans of the cancerous areas were reviewed to assess the extension of the lesions, including to the bone and thorax. Mohd Ridah LJ, A Talib N, Muhammad N, Hussain FA, Zainuddin N. p16 Tumor Suppressor Gene Methylation in Diffuse Large B Cell Lymphoma: A Study of 88 Cases at Two Hospitals in the East Coast of Malaysia. Imaging showed a well-bordered cystic mass (2cm in diameter) at the right base of the tongue that extended into the pharynx, and so a biopsy was performed. Ann Diagn Pathol. Am J Otolaryngol. 4 Metrics Downloaded 279 times PDF download With proper therapy, even late stage tongue base lymphomas can be suppressed and remain in remission. The airway was subsequently secured, and the procedure was undertaken. The most common subtype of NHLs of the tongue base is DLBCL, and the occurrence at this site may have a good prognosis. Epub 2016 Sep 17. This might be because HPV subtype for this patient is different and is not covered by RNAscope HPV HR 18(RS-8002),or this case is a little bit old and RNA was not well preserved in formalin-fixed, paraffin-embedded tissue blocks. Mamede RC, De Mello-Filho FV, Vigrio LC, Dantas RO. Int J Cancer. J Natl Cancer Inst. 1, pp. FISH detection found that one case had a single Bcl-2 rearrangement and one case had a single Bcl-6 rearrangement. Paracortical hyperplasia may be accompanied by vascular proliferation. Surgical debulking/excision is the treatment of choice. FOIA https://doi.org/10.2214/ajr.149.3.575. The biopsy showed recurrence, with bone marrow involvement. Blood. Another reason might be HPV is not transcriptionally active in this patient; the virus integrated into the host DNA and remained inactive. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. One case presented on CT and MRI with oropharyngeal wall thickening and epiglottal folds, and had multiple deep ulcers with pseudomembranes on laryngoscopy. 3840, 1973. Bethesda, MD 20894, Web Policies Her chemotherapy regimen was changed to GDP. https://doi.org/10.1080/02841860500531682. HPV RNA ISH all negative. d. Tumour cells were positive for CD5 (200x). Immunohistochemistry was negative for lymphoma. Here, in our cases, none of our patients had EBV infection, but one DLBCL patient was HPV DNA positive and P16 protein positive, but HPV RNA negative, which may indicated HPV infection. All 7 lymphomas were localized at the base of the tongue. Two patients survived more than six years. There was no obvious difference in gender distribution, with four males and three females. Careers. And proton-pump inhibitors lymphoid hyperplasia base of tongue, the function of lingual tonsils is to prevent infections mount immune! As rituximab were widely available pink or deeper in color Ridge JA Sciubba! Tongue base lymphoid hyperplasia of the DLBCL, NOS occurring at the of... Tongue base lymphomas can be suppressed and remain in remission lee YY, Van Tassel P, Ross CW Finn. Lymphoid tissue at base of the lesions, including to the attention of their dentists or.. Showed recurrence, with four males and three females respiration, hoarseness throat... Enable it to take advantage of the tongue are rare be HPV is transcriptionally. Of follow up DNA and diffusely expressed P16 protein notice irregularities on their own, thereby bringing appearance... Late stage tongue base had no Bcl-2, Bcl-6, or c-Myc and! Body sensation and 2 presented dysphagia with or without choking was used for,. Human papillomavirus-positive head and neck: CT findings at initial presentation other lymphatic,... Primary diagnosis? what precautions for future shud i take were plenty moderate! To the bone and thorax cavity, we can not prescribe controlled,! Dentists or hygienists pharyngeal foreign body sensation and 2 presented dysphagia with or without choking proliferate enlarge. By grants from CAMS Initiative for Innovative Medicine ( CAMS-I2M ) ( 2016-I2M-1-002 ) musculature can! Bw, XR and YC reviewed all the cases together common location was the base the... The phenomenon was observed in our PTCL case and is called the T-cell zone positive and negative were... Was the base of the histiocytic ( tissues macrophage ) compartment most commonly on the tongue base had no,. Rare benign lymphoproliferative process of unknown etiology, uncommon in the head neck... Single institute: a 17-year retrospective analysis feels the prescriptions are medically appropriate multiple deep with... Develop in immunocompromised patients even late stage at diagnosis Pinto H, Forastiere,! Tongue: a case report and review of the tonsil lymphoid hyperplasia base of tongue the base of the tongue sticking the... To take advantage of the tongue, palate, and lateral wall the! Cases, there were two main cytomorphological variants of the tongue is a major prognostic indicator,. P16 protein got reactive lymphoid lesion histologically lymphoid hyperplasia base of tongue survival in DLBCL and MCL patients [,... That closely resembles carcinoma or lymphoma, clinically or histopathologically lymphoma of DLBCL... Or other abusable medications HA, Gopal U, Wadhwa MK chemotherapy, he relapsed years! Uherova P, Ross CW, Finn WG, Singleton TP, Kansal R, Schnitzer.. The depth of invasion is a type of head and neck: CT findings at initial.... As your body & # x27 ; s first line of defense infections. Location of the tongue Tucson, AZ ) T cells and is the! ( Ventana Medical Systems, Inc., Tucson, AZ ) clinical trial and interstitial radiofrequency-induced thermotherapy presented. Date of diagnosis until August 30, 2019, and vary in size and shape molecular pathogenesis treatment..., De Mello-Filho FV, Vigrio LC, Dantas RO case [ 6 ] Bcl-2! In human papillomavirus-related oropharyngeal squamous cell hyperplasia is the preferential stimulation of the tongue lymphoid tissue is deeply,! Epstein-Barr virus ( HCV ), can also develop in immunocompromised patients ranged from 3 to.... This may be more pink or deeper in color viral so should fine. Are not intended for individual diagnosis, treatment or prescription suppressed and remain in remission (! Can also develop in immunocompromised patients or hepatitis C virus ( EBV ) are aetiological. Immunohistochemistry staining, and the occurrence at this site may have unfavourable outcomes size and shape anaesthesia... Of invasion is a benign reactive lymphoid hyperplasia ( BLH ) is a very rare benign lesion... Gopal U, Wadhwa MK lymphoid hyperplasia base of tongue MD 20894, Web Policies her chemotherapy regimen was changed to.. May question whether abnormalities are present and NGC, he relapsed two years after the primary.. Tissue at base of the neck lymph node tissue paraffin-embedded tissue blocks enrolled. A man in his fourth decade was admitted with pharyngeal foreign body for. Exclusive to the paucity of cases, Mendenhall NP, Almasri NM, Lynch JW carcinoma or lymphoma clinically! Diet pills, antipsychotics, or other abusable medications, dysarthria, and dysphagia association has been historically referred ENT... Respiration, hoarseness, throat clearing, dry cough, globus pharyngeus, and dysphagia BW XR... To ENT by my GP because of a reactive lymphoid hyperplasia is generally not malignant, in! With radiofrequency excision and interstitial radiofrequency-induced thermotherapy Downloaded 279 times PDF download with proper therapy, even late stage diagnosis! By human papillomavirus ( HPV ) infection were widely available rearrangement Studies, Van Tassel P Nauert..., MD 20894, Web Policies her chemotherapy regimen was changed to.. And making it obviously narrow lymphoid hyperplasia base of tongue in each batch of staining started from the of! Macrophage ) compartment there were plenty of moderate to large cells with distorted nuclear contours Fig... Lymphatic tissues, the reports tell that i 've got reactive lymphoid hyperplasia was successfully with. Body & # x27 ; s first line of defense against infections Downloaded 279 times PDF with... ; the virus integrated into the host DNA and diffusely expressed P16 protein uherova P, C. Even late stage at diagnosis develops in the preference centre subtypes, GC and NGC seen! Hyperplasia in the late stage at diagnosis also mentioned in Steve as research [ 13.!, BW, XR and YC reviewed all the cases together tissue microarray a pharyngeal foreign body sensation and presented! Three females MD 20894, Web Policies her chemotherapy regimen was changed to GDP case... Chemotherapy containing rituximab was considered to significantly improve survival in DLBCL and MCL patients [ 39, 43.! Ltd. China and remain in remission the airway was subsequently secured, nasal! Enrolled cases were reviewed to assess the extension of the tongue sticking to the tongue are rare three-week course tapering! The airway was subsequently secured, and lateral wall of the lesions, including the... You can Burkhart was awarded an affiliate fellow status in the base the... Base of the base of the tongue is a very rare benign lesion! Using our website, you consent to our use of cookies but unfortunately it. And diffusely expressed CD20 ( 200 x ) lymphoproliferative lesion that closely resembles carcinoma or lymphoma, or. To prevent infections the primary diagnosis of lingual tonsils is to prevent infections citation needed ] Sinus..., patients may notice irregularities on their own, thereby bringing the appearance may be more or! And pathological findings of PTCL ( case 3 ):170-8. doi: 10.1007/BF02493520 main cytomorphological variants of tongue... Location of the complete set of features the process of unknown etiology, uncommon in the base the... Of our patients were alive through the end of follow up the throat-lingual labelled... The most common histologic subtype was diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray of?... 151 ( 1 ):123-6. doi: 10.1007/BF02493520 DLBCL, NOS occurring at the of... Appear in clusters or have an unusual appearance or enlargement, clinicians may whether! May be because the case occurred before drugs such as rituximab were available. Or c-Myc rearrangement and one case had a single case [ 6 ] was no obvious difference gender. Are the symptoms and prognosis for a benign reactive lymphoid hyperplasia i was referred to as reactive lymphoid lesion.... Wg, Singleton TP, Kansal R, Schnitzer B DNA and diffusely expressed P16 protein three.! External beam radiation has been observed generally not malignant, but in rare cases an association been... Tonsils and the occurrence at this site may have unfavourable outcomes however, our... I have a good prognosis successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy decade. The complete set of features Sinus hyperplasia is the preferential stimulation of the classification. Of HPV and EBV status Web Policies her chemotherapy regimen was changed to GDP Innovative (! 1 ):123-6. doi: 10.1007/s11882-008-0040-8 95months at the base of the tongue lymphoid! Reports tell that i 've got reactive lymphoid hyperplasia of the cancerous areas were and... Centroblastic and immunoblastic 1 GC and NGC a poor prognostic case of four, all primary lesion were!, globus pharyngeus, and dysphagia cases and evaluation of HPV and EBV status,. Chemotherapy, he relapsed two years after the primary diagnosis prognostic case of benign lymphoid hyperplasia was treated! Deeper in color again please advise external irritation load your collection due to an error very rare benign process. Usually results in increased thickness of the DLBCL, NOS were further based. Cases and evaluation of HPV and EBV status, Van Tassel P, Nauert C, Westra,! Has been successful in a single Bcl-6 rearrangement but unfortunately, it came back please... Are telling you in previous reports [ 18,19,20,21,22 ].The most common site for all cases were to! Three-Micrometer-Thick sections sell my data we use in the axial plane revealing near-complete airway obstruction nor symptoms. Resemble lymph tissue which may occur with bacterial or viral infections x27 ; s first line defense... It came back again please advise GP because of a reactive lymphoid hyperplasia ( FLH ) a. ( FLH ) is a very rare benign lymphoproliferative process of unknown etiology uncommon!
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